Effective pulmonary capillary pressure during hyperdynamic porcine endotoxemia

Effective pulmonary capillary pressure.

The adult respiratory distress syndrome (ARDS) is almost invariably accompanied by permeability pulmonary oedema, usually appearing in the first few hours [1, 2]. The extent and therefore the seriousness of this oedema is proportional to the filtration of fluid and proteins through the pulmonary vascular endothelium. The extreme sensitivity of this filtration to variations of capillary pressure...

Biphasic changes in left ventricular function during hyperdynamic endotoxemia.

Cardiac contractility was studied in a clinically relevant conscious swine model simulating human hemodynamics during endotoxemia. The slope of the end-systolic pressure-volume relationship [end-systolic elastance ( E ES)] was used as a load-independent contractility index. Chronic instrumentation in 10 pigs included two pairs of endocardial ultrasonic crystals for measuring internal major and ...

Pulmonary capillary pressure in pulmonary hypertension

INTRODUCTION Pulmonary capillary pressure (PCP), together with the time constants of the various vascular compartments, define the dynamics of the pulmonary vascular system. Our objective in the present study was to estimate PCPs and time constants of the vascular system in patients with idiopathic pulmonary arterial hypertension (IPAH), and compare them with these measures in patients with acu...

Pulmonary Capillary Leak Syndrome

Effects of adenosine on the functions of circulating polymorphonuclear leukocytes during hyperdynamic endotoxemia.

Endotoxin-activated polymorphonuclear leukocytes (PMNL) adhere to the vascular endothelium and cause damage by the release of toxic superoxide anions (O2-). Because adenosine is a potent inhibitor of PMNL in vitro, the present study investigates the effects of this nucleoside on the functions of circulating PMNL in a standardized porcine model of hyperdynamic endotoxemia. Ten anesthesized pigs ...